Additionally, the distribution of STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6 expression in CD4+ T cells in pan-cancer were also clearly illustrated (Figure 6B; Supplementary Figures S11A–G), which showed that STAT1 and STAT2 expression were notably up-regulated in CD4+ Treg cell with marker OSA1 and CD4+ T cell with ISG IFIT1. The gene discussed is STAT5A; the disease is cancer.