That indicated potential relationships between STAT and rejection of allograft, interferon response, inflammatory response and IL6-JAK-STAT3 signaling pathway in pan-cancer, which was consistent with relevant previous research (Darnell et al., 1994; Platanias, 2005; Stepkowski and Kirken, 2006; Mimura et al., 2018; Dambal et al., 2020). This evidence concerns the gene IL6 and cancer.