In other examples of functional effects, rs9611280 missense variant in TNRC6B gene has been shown to affect the splicing of the mRNA (Martin-Guerrero et al., 2015), whereas rs4961280, located in the promoter region of AGO2 was found to upregulate the expression of the gene in prostate cancer patients (Nikolić et al., 2017). Here, TNRC6B is linked to Familial prostate cancer.