AGO2 and Familial prostate cancer: In other examples of functional effects, rs9611280 missense variant in TNRC6B gene has been shown to affect the splicing of the mRNA (Martin-Guerrero et al., 2015), whereas rs4961280, located in the promoter region of AGO2 was found to upregulate the expression of the gene in prostate cancer patients (Nikolić et al., 2017).