For example, SNVs in DROSHA have been associated with gastric cancer and susceptibility to congenital heart disease (Song et al., 2017; Borghini et al., 2021), whereas gene variants in DICER1 occur at significantly higher allele frequencies in individuals with endometrial and hepatocellular carcinoma than in the healthy population (Wang et al., 2017; Oz et al., 2018). This evidence concerns the gene DICER1 and congenital heart disease.