It has long been proposed that MEG3 acts as a significant tumor suppressor gene according to its characteristic decreased expression in some cancers, including non-functional pituitary adenoma, colorectal cancer, non-small cell lung cancer, hepatocellular carcinoma, neurospongioma, and meningeoma (Li et al., 2019a) (Lu et al., 2013). The gene discussed is MEG3; the disease is hepatocellular carcinoma.