We conducted a search of the current literature using keywords including lncR Meg3, heart failure, cardiomyopathy, myocardial infarction, cerebrovascular diseases, ischemic stroke, ischemia-reperfusion, atherosclerosis, congenital heart disease, and biological functions in PubMed, Web of Science, Springer, and Elsevier ScienceDirect in the latest 10 years. The gene discussed is MEG3; the disease is heart failure.