EZH2 and neoplasm: The PRC2 complex is composed of several subunits (EZH2, EED, SUZ12, JARID2 and Rbap46.48), which are often amplified in MB (Bunt et al., 2013; Dubuc et al., 2013), and their actions leads to an elevated level of H3K27me3 by repressing specific tumor suppressor genes, thus facilitating tumor development (Greer and Shi, 2012).