IGF1 and neoplasm: In this regard, SHH MB cells have been reported with the ability to transdifferentiate into interleukin-4-(IL-4) secreting astrocytes, which stimulate microglia to release insulin-like growth factor 1 (IGF1) together with the immunosuppressive IL-10 (Yao et al., 2020) both of great importance on mediating tumor progression.