Additionally, in GR3 MB, tumor-associated astrocytes produce high levels of CCL2 chemokine (Liu et al., 2020) that has been also shown to promote leptomeningeal metastasis (Garzia et al., 2018) and to act as a chemoattractant for other immune cells, including monocytes and bone marrow-derived macrophages (Maximov et al., 2019) with a tumor-promoting function, showing definitively an M2-like gene expression profile in SHH MB model (Margol et al., 2015). The gene discussed is CCL2; the disease is neoplasm.