Numerous studies have shown that the overexpression of GPI/AMF is connected with poor prognosis, such as tumor invasion and the increased mortality in many cancer types, including gastrointestinal (Gong et al., 2005), kidney, lung and breast cancers (Baumann et al., 1990; Nabi et al., 1991; Jiang et al., 2006). The gene discussed is GPI; the disease is cancer.