In the LPS-inducedALI mouse model, we detected the sEH level and demonstrated the sEHoverexpression in ALI mice (Figure S14).Next, we found that WED treatment significantly inhibited the decreaseof levels of sEH substrates, such as 11,12-EET and 14,15-EET, exceptfor in the case of low dose WED treatment (5 mg/kg, Figures 9A and S15). This evidence concerns the gene EPHX2 and acute respiratory distress syndrome.