To test for damage-mutationmatches, we focused on mutation sites from The Cancer Genome Atlas(TCGA) in 18 statistically significant mutated genes of lung adenocarcinomas.41 From these, N2-BPDE-dGwas detected at least twice, i.e., in at least two chemical exposureconditions, in four genes, namely, the chromatin modifying gene SMARCA4and the tumor suppressor genes CDKN2A, KEAP1 and TP53 (two damage-mutationmatches in TP53 and one in each of the other genes). This evidence concerns the gene CDKN2A and lung adenocarcinoma.