Increasing thestringency of the analysis, among these, we selected two mutationsites located in tumor suppressor genes CDKN2A (Figure 4e) and KEAP1 (Figure 4f) as they had the BPDE damage called byat least two reads across experimental replicates of a given condition.The identified damage-mutation match in CDKN2A was the most frequentlymutated site of this gene in the lung adenocarcinoma data, and oneof the top 0.007% (28/381,737) most frequently mutated sites genome-widein lung carcinomas (TCGA). The gene discussed is KEAP1; the disease is lung carcinoma.