In addition, EGR1 and AChE mRNA were both significantly negatively correlated with the contents of soluble Aβ(1–42) (r = –0.57, P = 0.01, Figure 2E and r = –0.64, P = 0.005, Figure 2F, respectively) in pooled 3xTg-AD males but not females (r = –0.23, P = 0.35, Figure 2G and r = 0.32, P = 0.18, Figure 2H, respectively). Here, EGR1 is linked to Alzheimer disease.