We previously reported that treatment of T2DM stroke in male mice with exosomes harvested from human umbilical cord blood (HUCBC) derived CD133 + cells (early progenitor endothelial cells in cord blood, here referred to as CD133 + Exo), significantly improves cardiac function via reducing inflammation, oxidative stress, fibrosis, and increasing microRNA 126 expression at 28 days post-stroke compared to control T2DM-stroke mice (Venkat et al., 2021). This evidence concerns the gene PROM1 and type 2 diabetes mellitus.