In fact, mixed responses on histopathological samples combining different ratios of inflammation and tumor proliferation are found in up to 28% of patients.8 The occurrence of PsPD has been associated with the O(6)-methylguanine-DNA methyltransferase (MGMT) promoter methylation and the isocitrate dehydrogenase (IDH) mutation status, but neither of these molecular information nor other available demographic data appear self-sufficient to reliably predict a possible PsPD.9,10. Here, MGMT is linked to neoplasm.