NTRK2 and central nervous system cancer: BDNF and TrkB expression are increased in cancers of various types, including gliomas.84,85 Intrinsic expression of BDNF and TrkB has been noted in C6 glioma cells.86 and exogenous exposure of these cells to recombinant murine mature BDNF increased proliferation, where antibody-mediated blocking of the BDNF abrogated these effects in a dose-dependent fashion.