NLGN3 and central nervous system cancer: The NF1 mutation, synergistically with optogenetic stimulation of the retina, has been shown to contribute to NLGN3 secretion and optic glioma growth and further drives neuronal hyperexcitability and tumor progression through altered hyperpolarization-activated cyclic nucleotide-gated channels.97 In a similar context, sensory input of other types impacts glioma formation as well, particularly in the olfactory bulb wherein olfactory receptor neurons were shown to excite mitral and tufted cells into releasing IGF-1, thereby promoting gliomagenesis.98