EGLN1 and neoplasm: The dimerization of HIF-1α and HIF-1β leads to the upregulation of proangiogenic genes, such as VEGF, fibroblast growth factor, and several others, which leads to an increase in angiogenesis, invasiveness, and tumor migration.149 Depending on the cellular context, PHD2 exerts both pro- and antitumor properties.