While some studies provide evidence of its vital role in fibrosis and dysfunction of the remodelling heart (Yu et al., 2013; Martinez-Martinez et al., 2015) other investigations using galectin-3 knockout mice demonstrated that this is not a critical modulator of cardiac fibrosis but may be able to delay the hypertrophic response (Frunza et al., 2016; Nguyen et al., 2018). The gene discussed is LGALS3; the disease is fibrosis.