To further assist in the understanding of ATTR V30M effect in the cardiac ECM structure and dynamics, we aimed to study a particular animal model, HSF ± hTTR V30M transgenic mice (Santos et al., 2010) which has been extensively investigated in the context of peripheral and central nervous systems in ATTRV30M amyloidosis and it has proved crucial for the understanding of the pathogenesis of ATTR amyloidogenesis as well as in the preclinical evaluation of pharmacotherapy and gene therapy studies (Cardoso et al., 2010; Ferreira et al., 2014; Butler et al., 2016; Ferreira et al., 2016). This evidence concerns the gene TTR and amyloidosis.