Because metastasis is the major cause of death in patients with breast cancer, it becomes critical to investigate the molecular mechanisms whereby certain factors such as actin cytoskeleton remodeling proteins (WAVE2), regulators of cell adhesion and spreading (integrins), and regulators of global posttranscriptional repression (miRNAs), and how interrelationships between these molecular mechanisms impact cancer progression and metastasis, which may provide novel therapeutic alternatives and opportunities to treat breast cancer. The gene discussed is WASF2; the disease is cancer.