In the current study, we used a combination of global transcriptomics (RNA-seq), bioinformatics, genetic manipulation of gene expression, different biochemical and cell imaging analyses in vitro, in addition to in vivo mouse models for TNBC, as well as interrogation of public human breast cancer datasets, to investigate the potential role of WAVE2 and its downstream effectors (miR-29 and ITGB1) in TNBC tumor progression and metastasis. The gene discussed is ITGB1; the disease is breast cancer.