BRCA1 and neoplasm: The mutational signature making the greatest contribution was Signature 3, associated with BRCA1/BRCA2 inactivation (Supplementary Fig. S3A); however, it was only significantly enriched in two tumor samples [abdominal wall nodule In2 (60%) and pancreatic metastasis Pa2 (41%)] and did not reach the threshold for statistical significance in other samples.