Another gene, ADAMTS9, a tumor suppressor (Lo et al., 2010), was found to be significantly downregulated and alternatively spliced through intron retention in the same cell line; while the tumor suppressor ZMYND8, and the oncogene ZNF217 involved in tumor stemness and metastasis (Cohen et al., 2015; Li et al., 2016) were found to be downregulated and upregulated, respectively; a gene involved in the regulation of RNA processing (Federico et al., 2017), INTS2, was upregulated as well. The gene discussed is INTS2; the disease is neoplasm.