Hematopoietic cell-specific substrate protein 1-associated protein X-1 (HAX1) and phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3), which are abundant in sEVs secreted by NPC cells, promote angiogenesis and accelerate the growth of NPC in vitro and in vivo (You et al., 2016; Gu et al., 2017). The gene discussed is PFKFB3; the disease is nasopharyngeal carcinoma.