Recently, it has been shown that sEV endoplasmic reticulum-resident protein 44 (ERp44), which is produced upon endoplasmic reticulum (ER) stress in NPC cells, is involved in resistance to chemotherapy with platinum drugs, suggesting that ERp44 might be a new therapeutic target (Xia et al., 2021). This evidence concerns the gene ERP44 and nasopharyngeal carcinoma.