As mentioned above, the dysregulation of signaling will lead to ALL, Martelli et al. revealed that target inhibition of PI3K or mTOR pathway might be a potential therapy (Martelli et al., 2011), and recently Banerjee et al. used copper chelate inducing ALL apoptosis through redox imbalance and inhibition of PI3K/Akt expression (Banerjee et al., 2016), and SCL may be an evaluation of the disease (Legutko, 1978). Here, MTOR is linked to acute lymphoblastic leukemia.