To date, over 600 disease-causing rare LMNA variants are characterized (Worman and Bonne, 2007; Dittmer and Misteli, 2011), and these “laminopathies” are associated with heterogeneous clinical phenotypes, including neuromuscular, cardiac, and metabolic disorders (Bertrand et al., 2011; Worman, 2012; Maggi et al., 2014). The gene discussed is LMNA; the disease is laminopathy.