Mutations of CASA members in humans lead to severe human diseases, including skeletal muscle myopathies, cardiomyopathies (Martin et al., 2021), kidney filtration failure (proteinuria) (Perico et al., 2016), Alzheimer disease and other neuropathies (Counts et al., 2014; Datta et al., 2017; Ji et al., 2019; Adriaenssens et al., 2020). This evidence concerns the gene CSN1S1 and Alzheimer disease.