Also, the modulation of HER2 by topographical stimuli in HER2+ breast cancer cells was documented before by Daverey et al., where micro-gratings (grooves) were found to downregulate HER2 expression in HER2+ cell lines BT-474 and SKBr3 (Daverey et al., 2022). The gene discussed is ERBB2; the disease is breast carcinoma.