Similarly, nano- and micro-grating patterns enhanced the proportion of the CD44+/CD24-subpopulation in MCF-7 cells (Tan et al., 2015) and decreased the expression of HER2 in HER2+ breast cancer cells BT-474 and SKBr3, validating the vast range of cell phenotypic changes induced by topographical stimuli (Daverey et al., 2022). Here, ERBB2 is linked to breast cancer.