Various studies have also shown that SFRP1 can promote the activation of the canonical WNT pathway (Üren et al., 2000; Xavier et al., 2014; Cruz-Hernández et al., 2020), Considering the results of this research and those described in the literature, we propose a possible mechanism by which the loss of SFRP1 expression in epithelial cells together with SFRP1-mediated stromal signalling may support the activation of the WNT/β-catenin pathway and contribute to the development of stem-like properties in prostate cancer (Figure 7). This evidence concerns the gene SFRP1 and prostate cancer.