IL2 and cancer: This CD122-selective IL-2 complex (IL-2c) is the focus of this commentary as several groups have previously shown the efficacy of IL-2c in multiple murine cancer models including B16/F10 melanoma [9,10,30], pancreatic cancer model [8], BCL1 leukemia [9], TRAMP-C1 sarcoma [14], and orthotopic bladder cancer [31].