INS and adenoma: Moreover, the three groups differ in genes encoding kinases: TBX19-derived adenomas show upregulation of MERTK and STK17B and alterations in VEGFA-VEGFR, EGF-EGFR, and insulin signaling pathways; NR5A1-derived tumors show upregulation of ETNK2 and PIK3C2G and changes in MAPK, ErbB, and RAS signaling; and POU1F1-derived adenomas show upregulation of PIP5K1B and NEK10 and alterations in phosphatidylinositol, insulin, and phospholipase D signaling pathways.