Whole-exome sequencing of one patient with an ACTH-producing CA, one CCA, one corticotrophinoma occurring in a CD patient who developed Nelson syndrome after adrenalectomy, three SCAs, and four ACTH-secreting PAs causing CD showed that the neoplasm with the highest number of genomic abnormalities was the ACTH-CA, followed by the CCA and the CD tissues. Here, POMC is linked to cancer.