ATIC and lung adenocarcinoma: The level of ATIC (5-Aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase catalyzing enzyme in the de novo purine biosynthetic pathway (Sugita et al., 1997)), which is known to facilitate cell growth and migration by upregulating Myc expression in lung adenocarcinoma (Niu et al., 2022), was slightly increased, as Nef expression was increased (Figure 2C).