Interestingly, dysbiosis of intestinal flora alters the levels of bile acid metabolites, with most conjugated bile acids,such as TCDCA, TDCA, and GDCA increasing and TDCA or GDCA promoting the proliferation of hepatic stellate cells and the formation of liver fibrosis by activating the TGR5-ERK1/2 and P38 MAPK signaling pathways (Inagaki et al., 2006). Here, GNAT3 is linked to Hepatic fibrosis.