Many studies reported the beneficial effect of Curcumin on diabetic peripheral neuropathy through antioxidant activity (Zhao et al., 2014), activation of the opioid system (Banafshe et al., 2014), suppression of TNF alpha expression (Daugherty et al., 2018), reduction of depression and anxiety (Asadi et al., 2020), modulation of the activity of DRG astrocytes and neurons (Park et al., 2021), inhibition of Schwann cell apoptosis and promoting nerve growth factor (NGF) (Zhang et al., 2022). Here, NGF is linked to major depressive disorder.