The SIN3 transcriptional regulator family 3 A (SIN3A)-HDAC1/2 transcription repressor complex silenced bone morphogenetic protein 6 (BMP6) expression, which increased the metastatic potential and oncogenic potential of melanoma cells by suppressing BMP6-activated mothers against DPP homolog 5 signaling [33]. The gene discussed is BMP6; the disease is melanoma.