Depletion of HDAC2 in PC cell lines enhanced the sensitivity of PC cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by increasing the expression of TRAIL receptor 1 (DR5), caspase 8 activity, and cleavage of BH3-only protein Bid [47]. Here, TNFRSF10B is linked to pachyonychia congenita.