We assessed the degree of core and intermediate in the PPI network and screened 10 genes to be screened as key diagnostic genes for osteoarthritis and myelodysplastic syndromes, top 10 hub genes were BLNK, SOCS2, SIK1, RGS1, STK17B, MEF2C, PDE4B, PIM1, RRASE, and PTPN6 (Figure 4D). This evidence concerns the gene SIK1 and myelodysplastic syndrome.