Since both periodontitis and OSA are associated with systemic inflammations possibly involving similar pathways, the objective of this study was to compare the expression of pro-inflammatory cytokines IL-1β, IL-6, IL-17A, IL-33, and TNF-α simultaneously in saliva and GCF in patients with OSA as biomarkers associated with the periodontal condition and its clinical status. This evidence concerns the gene IL6 and obstructive sleep apnea syndrome.