For example, hyperphosphorylated and ubiquitinated TDP-43 inclusions in the cytoplasm of cells in the nervous system represent a major pathological feature of amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration (FTLD) (Dugger and Dickson, 2017). Here, TARDBP is linked to amyotrophic lateral sclerosis.