Studies have shown that several genetic mutations, such as those of superoxide dismutase 1 (SOD1), transactivating response element DNA-binding protein-43 (TDP-43), chromosome 9 open reading frame 72 (C9orf72), and fused in sarcoma/translocated in liposarcoma (FUS/TLS), can cause accumulation of insoluble proteins and impaired intracellular protein homeostasis, which leads to ALS (Amado and Davidson, 2021). The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.