The outcomes showed that IP-10 protein level (SMD = −0.19, 95% CI: −0.63 to 0.24) and IL-8 protein level (SMD = 0.61, 95% CI: −0.26 to 1.48) were not significantly different in CSF samples from AD patients and healthy individuals (Figures 3A, B). This evidence concerns the gene CXCL8 and Alzheimer disease.