Striatal demyelination was further confirmed using MBP immunostaining along with neurofilament heavy chain, a major structural component of the axonal cytoskeleton, where we found significant reduction in MBP stained striosome and matrix area in 15-month old AD mice compared to WT mice (Figures 3C,D; Supplementary Figure 3). The gene discussed is NEFH; the disease is Alzheimer disease.