Exercise therapy improved cognitive performance mechanisms, such as increasing growth factors (Ruiz-González et al., 2021; Xue et al., 2022), modulating inflammatory cytokines (Hashiguchi et al., 2020; de Farias et al., 2021), alleviating oxidative stress (Hu et al., 2022), increasing cerebral blood flow (Lu et al., 2019; Tomoto et al., 2021), decreasing antibody concentrations (Giménez-Llort et al., 2013), and inhibiting tau phosphorylation from slowing the progression of dementia (Wang et al., 2021; Xu et al., 2022). The gene discussed is MAPT; the disease is dementia.