TNF and polycystic ovary syndrome: In recent years, studies have shown that the chronic inflammatory state of PCOS is not only manifested in the infiltration of macrophages and lymphocytes in the local pathology of ovary of patients with PCOS, but also the changes in the level of relevant inflammatory factors in vivo, such as hypersensitive C-reactive protein, interleukin-6, tumor necrosis factor, etc (50, 51).