As shown in the univariate forest plot (Figure 4A), 13 pyroptosis-related genes were significantly associated with the prevalence of T2D: DDX3X, GBP2, GSDMB, GSDMD, NLRP1, NOD2, PYCARD, TNFRSF21, APIP, CASP6, DHX9, TREM2, and ZBP1. LASSO regression was performed on these 13 genes. The gene discussed is GSDMD; the disease is type 2 diabetes mellitus.