GNAS and type 2 diabetes mellitus: Most of the other hub genes, including GCG (75), NEUROD1 (76), PCSK1 (77), ABCC8 (78), STMN2 (79), IAPP (80), KCNQ1 (81), NKX2-2 (82), SCG5 (83), CPE, and GNAS (84), have been strongly associated with the onset or development of T2D.