In the T2D group, the abundance of activated CD4+ T cells, activated dendritic cells, central memory CD8+ T cells, effector memory CD8+ T cells, macrophages, MDSC, natural killer cells, natural killer T cells, neutrophils, type 1 T helper cells, and type 17 T helper cells significantly increased, whereas the abundance of effector memory CD4+ T cells, immature dendritic cells, and memory B cells significantly decreased (Figure 9C). Here, CD8A is linked to type 2 diabetes mellitus.