Specifically, SARS-CoV-2 may directly trigger thyroid autoimmunity infecting thyroid follicular cells, where ACE-2 receptor is abundantly expressed (28); viral presence has indeed been retrieved in thyroid specimens (29, 30) and reactivity between TPO antigen and SARS-CoV-2 has been demonstrated in vitro, favoring the hypothesis of molecular mimicry (31). Here, TPO is linked to autoimmune thyroid disease.