MEN1 and pituitary tumor: A missense variant in exon 7 has been identified in family 2 (c.1021:p.Trp341Arg), which was previously described in two individuals with clinical MEN1: one with PHPT, GEP tract tumor and a non-functioning adrenal tumor (10) and another with PHPT, GEP tract tumor, and pituitary tumors (56).