Similarly to Mov13, oim mice have shown upregulation of Edn1, important for angiogenesis, osteoblastic proliferation and bone development, whereas Eln overexpression might be an attempt to compensate for the loss of bone extracellular matrix elasticity (30). High content of elastin was shown in biopsies of human OI type 4 and Ehlers-Danlos syndrome patients (70, 71). Due to the mixed effect of the transgenesis and possible development of lymphoma, the biological interpretation of the gene expression pattern in Mov13 mice remains unclear. This evidence concerns the gene EDN1 and osteogenesis imperfecta type 4.