TRH and pituitary apoplexy: Surgeries (in particular cardiac and orthopaedic), arterial pressure fluctuations, micro-embolism, cranial trauma, dynamic pituitary testing [in particular insulin tolerance test (ITT), TRH (thyrotropin releasing hormone) and GHRH (Growth Hormone Releasing Hormone) tests], anticoagulant and to a lesser extent dopamine-agonist therapy are the main factors which can predispose to pituitary apoplexy.