An OMIM description of the phenotype of Wolfram syndrome 1 (MIM: 222300) proposed a possible clinical phenotype of cardiomyopathy, but no relevant reports were found by searching the literature with the keywords including cardiomyopathy and WFS1. Previously reported cardiac abnormalities were mainly structural defects (25, 26). The gene discussed is WFS1; the disease is cardiomyopathy.