PLN and familial dilated cardiomyopathy: It is worth noting that although we did not measure Ca2+ transients, a limitation of our study, the modifications in PLB phosphorylation by CaMKII but not PKA in the diabetic myocardium suggest that specific subcellular cAMP/PKA and Ca2+/CaMKII pools might be preferentially impacted in DCM and would require further characterization.