In this study, we found, first, that previously identified asthma risk alleles in CDHR3, GSDMA, and GSDMB were associated with an increased rate of all ARIs, risk alleles in CDHR3 and GSDMA with an increased rate of RV-positive ARIs, and risk alleles in GSDMA, GSDMB, IKZF3, ZPBP2, and ORMDL3 with an increased risk of RSV-positive ARI. Here, ORMDL3 is linked to asthma.