While these observations suggest that inflammasome‐independent roles for AIM2 in gastrointestinal pathologies predominantly align with AIM2 expression and function in the epithelium, it is also noteworthy that AIM2 inflammasome activity intrinsic to the gut epithelium has been attributed to the regulation of intestinal homeostasis in mouse models of colitis in both epithelial and macrophages, specifically via IL‐18 production.27, 36. Here, IL18 is linked to colitis.