In this respect, in addition to AIM2, several other inflammasome‐associated components (via IL‐1β) that have been reported to contribute to gastric inflammation and pathology in Helicobacter infection mouse models, namely ASC and NLRP3,10, 21, 42 also play contrasting roles within a specific disease setting that are dependent on expression in specific cell types and stages of disease.43, 44, 45, 46. Here, AIM2 is linked to Helicobacter pylori infectious disease.