We also note that an inflammasome‐independent role for AIM2 that is intrinsic to the gut epithelium has been demonstrated in colon cancer, whereby AIM2 suppresses intestinal tumorigenesis in ApcMin/+ and DSS/AOM mouse models by modulating intestinal epithelial cell apoptosis and proliferation.25, 35. Here, AIM2 is linked to colonic neoplasm.