GSDMD and sickle cell disease: Lastly, GSDMD plays a vital role in inflammatory lung injury in sickle-cell disease (SCD), which promotes caspase-4/11 dependent activation of neutrophil-GSDMD and shedding of neutrophil extracellular traps (NETs) in the liver in P-selectin dependent manner.29 The NETs translocate to the lung and lead to neutrophil-platelet aggregation.29 Vats et al.29 further showed that inhibition of GSDMD using GSDMD-NT inhibitors Necrosulfamide and LDC7559, pan-caspase inhibitor Z-VAD-FMK38 alleviated lung vaso-occlusion in SCD.