CASP1 and acute kidney injury: Interestingly, the deletion of GSDMD in AKI mice models alleviated renal inflammation.93 Following this study, another group revealed that paricalcitol, a vitamin D receptor agonist, alleviates cisplatin-induced AKI by reducing pyroptosis through downregulation of NFκB κB/ NLRP3/cleaved caspase-1/GSDMD pathway.60 Moreoever, GSDMD is associated with AKI induced by radial contrast media such as iopromide.61