As myocardial hypertrophy is associated with chronic inflammation and increase in inflammatory cytokines, GSDMD-mediated inflammation also plays a role in myocardial hypertrophy and cardiac dysfunction.55, 69, 70 Han and colleagues55 investigated the effects of using DL-3-n-butylphthalide (NBP), a neuroprotective agent widely used in various Asian countries to treat ischemic stroke, in GSDMD-mediated inflammation. Here, GSDMD is linked to cardiac hypertrophy.