Inflammasomes play a critical role in SCI, resulting in inflammatory cell death.48, 49 Recent evidence demonstrated the therapeutic effects of inhibiting GSDMD and suppressing pyroptosis in SCI to reduce the inflammatory response.47, 34,50–52 Dai et al.50 demonstrated that ASC, caspase-1, and GSDMD in the canonical inflammasome pathway associated with pyroptosis, were significantly elevated in spinal cord injury rat models compared to the sham groups. This evidence concerns the gene GSDMD and spinal cord injury.