In more recent studies, GSDMD is also shown to be activated in acute myocardial infarction (AMI), indicating that pyroptosis plays an essential role in the progression of AMI.54, 66 Zhang et al.66 revealed that pro-inflammatory adipokine, retinol-binding protein 4 (RBP4), contributes to AMI by activating the canonical inflammasome NLRP3/Caspase-1/GSDMD-NT resulting in pyroptosis. This evidence concerns the gene NLRP3 and myocardial infarction.