GSDMD plays a pivotal role in circulating vesicles in endothelial cell lung injury including sepsis-mediated pulmonary vascular endothelial cell injury and ventilation-induced lung injury.73, 74 During a pathological condition of the vascular endothelium, microparticles encapsulating caspase-1 are being released, where they circulate and accumulate in areas of disordered blood flow.73, 75, 76 Mitra et al.73 revealed that GSDMD induced by LPS simulation is encapsulated with the active caspase-1 microparticles to induce endothelial cell death. This evidence concerns the gene CASP1 and Sepsis.