GSDMD specific deficiency in vascular smooth muscle cells alleviates abdominal aortic aneurysm (AAA) by reducing putrescine compound levels in the aorta.24 Inhibiting the synthesis of putrescine with difluoromethylornithine (DMFO), a compound in a clinical trial for Neuroblastoma, results in the prevention of AAA development. This evidence concerns the gene GSDMD and triple-A syndrome.