GSDMD and brain injury: In addition, another group demonstrated that pyroptosis occurs in neurons.22 They showed significantly high GSDMD expression on day one post-acute stroke.22 They further assessed the neuronal effects of VX765 treatment, a caspase-1 inhibitor, post-ischemia, which showed a significant reduction of GSDMD on day one and suppression of the canonical inflammasome pathway leading to neuroprotection following ischemic stroke.22 GSDMD-mediated pyroptosis was also shown in microglia after ischemia/reperfusion brain injury.