Wang and colleagues56 examined the effect of Dihydromyricetin (DHM), an anti-inflammatory flavonoid, in the cecal-ligation puncture model of sepsis to induce acute lung injury, which showed significant downregulation of lung inflammation by targeting the NLRP3/caspase-1/IL1β/IL18/GSDMD-NT pyroptosis pathway. The gene discussed is GSDMD; the disease is Sepsis.