Interestingly, one study showed that GSDMD specific deficiency in myeloid cells is protective hepatic-ischemia reperfusion injury (IRI), with no protective effects in GSDMD specific deficiency in hepatocytes cells.39 Lastly, GSDMD plays a crucial role in disseminated intravascular coagulation (DIC) in sepsis; GSDMD deficiency ameliorates thrombin generation, fibrin deposition, and platelet aggregation in the liver microvasculature.40 Here, GSDMD is linked to Disseminated intravascular coagulation.