32, 87 Wang et al.32 demonstrated that Honokiol targets the TLR4/NFκB suppressing gasdermin-D mediated pyroptosis through anti-inflammatory effects on DSS-induced colitis mice and LPS-induced RAW264.7 macrophages, making Honokiol a promising drug for UC.32 Lastly, GSDMD deficiency plays a role in gastric cancer (GC), where Wang et al.88 showed GSDMD downregulation in mouse GC tissue and human cell lines. The gene discussed is GSDMD; the disease is colitis.