Gasdermin (GSDM) is a family of proteins comprised six members: GSDMA, GSDMB, GSDMC, GSDMD, GSDME/DNFA5, and PVJK/GSDMF.6 They are mostly composed of C-terminal, N-terminal and linker domains.7 The first GSDM protein was discovered in 1998 as a mutation in age-related hearing loss as DNFA5.6, 7 In 2000, Saeki et al.8 identified GSDM gene expressed in GI tract and skin on mouse chromosome 11.7–9 GSDMD was determined to be required for pyroptosis in 2015.10–12 Shi et al.10 showed that cleavage of GSDMD by caspase-1 and other inflammatory caspases can drive pyroptosis. This evidence concerns the gene GSDMD and presbycusis.