Moreover, NLRP3 inflammasome was expressed in KD-treated endothelial cells, resulting in activation of downstream NLRP3-mediated pyroptosis, including cleaved caspase-1 GSDMD-NT, mature IL1β, and IL8.68 These results suggest the role of endothelial cell pyroptosis in KD and how targeting NLRP3-mediated pyroptosis, including GSDMD-NT, could be a potential targeted therapy for KD and other related conditions with systemic inflammation. Here, GSDMD is linked to inflammatory response.