Lei and colleagues revealed the role of pyroptosis and oxidative stress in myocardial infarction (MI), where they examined GSDMD and its transcription factor NFκB.62 Using the myocardial infarction rat model, they revealed that GSDMD-mediated pyroptosis by NLRP3 inflammasome results in cardiomyocyte loss following MI. Here, GSDMD is linked to myocardial infarction.