GSDME and neoplasm: Pyroptosis is a programmed cell death pathway that can effectively promote anti‐tumor immunity by releasing intracellular proinflammatory content and tumor antigen in the pyroptosis process.[3] In particular, combining photothermal reagents and small‐molecule drugs promotes pyroptosis.[4] Small‐molecule drugs can enhance the expression of gasdermin E (GSDME) in tumor cells.