DERL3 and cancer: Regarding cervical epithelial cells, we innovatively identified three unique clusters, including ‘SLC5A8+ DERL3+ HPV‐related normal,’ ‘VSIG1+ CASC9+ HPV‐related HSIL’ and ‘CASP14+ CALML5+ HPV‐related cancer.’ Excitingly, we discovered critical node genes that determined the cell fate between HPV infection and cervical lesions and cervical lesions and CC.