On the other hand, cluster 2, representing HSIL, manifested high cellular motor capacity, specifically expressing genes related to cell adhesion (CDH16, CDH17 and VSIG1)11, 12 and extracellular matrix degradation (CTSE) (Figure 2E), thus potentially promoting the expansion of atypical cells in intraepithelial neoplasia progression. This evidence concerns the gene CDH16 and intraepithelial neoplasia.