(3) In the histological maps of CC, the spatial coexpression of ligand–receptor pairs, such as WNT7B (‘CASP14, CALML5+ HPV‐related CA cluster’)‐FZD1 (cDC), representing the aggressiveness of cancer, CEACAM5 (‘CASP14, CALML5+ HPV‐related CA cluster’)‐CD1D (cDC), manifesting tumour‐associated antigen presentation and TNFSF10 (‘CASP14, CALML5+ HPV‐related CA cluster’)‐TNFRSF11B (macrophages), embodying tumour escape through anti‐apoptosis, were remarkably discovered, fully demonstrating the malignant features of cancer. The gene discussed is CALML5; the disease is cancer.