Regarding cervical epithelial cells, we innovatively identified three unique clusters, including ‘SLC5A8+ DERL3+ HPV‐related normal,’ ‘VSIG1+ CASC9+ HPV‐related HSIL’ and ‘CASP14+ CALML5+ HPV‐related cancer.’ Excitingly, we discovered critical node genes that determined the cell fate between HPV infection and cervical lesions and cervical lesions and CC. This evidence concerns the gene CASP14 and cancer.