As expected, the Tn cluster tended to be nonactivated, whereas Temra, featuring high expression of CX3CR1, presented a high cytotoxicity signature (PRF1, KLRD1), which was reported to be involved in fighting against persistent viral infection and infiltration into tumour regions with high cytotoxicity and migratory abilities.29, 30. Here, KLRD1 is linked to viral infectious disease.