PDHA1 and neoplasm: In addition, it has also been shown that lysine acetylation of PDHA1 and PDP1 is very common in both epidermal growth factor (EGF)-stimulated cells and various human cancer cells, and that acetylation of K202 is able to inhibit PDP1 by dissociating its fifth PDHA1, both of which have a great role in promoting glycolysis and tumor development in cancer cells25.