We conducted Kaplan–Meier analysis in the Meta-validation cohort and observed that patients with high PHF6 had shorter relapse-free survival (RFS) time than those with low PHF6, in line with the notion that PHF6 correlates with tumor recurrence (log-rank test P = 8.3e − 07, N = 2032, Fig. 6J). The gene discussed is PHF6; the disease is neoplasm.