However, several selection criteria, i.e., the Milan and UCSF criteria, limit the number of tumor nodules to a maximum of 3 [4, 5, 7, 12], while others, i.e., the alpha-fetoprotein (AFP), Metroticket 2.0, and Up-to-7 models, include HCC patients with more than 3 tumor nodules [6, 9, 10]. This evidence concerns the gene AFP and hepatocellular carcinoma.